Juventus has confirmed that Leonardo Bonucci tested positive for coronavirus.
Since returning from international service with Italy, the 33-year-old central defender took the exam again on Thursday.
Andrea Pirlo has caused him a selection nightmare ahead of some important Serie A fixtures, but he is now isolating himself at home.
Italy’s flawless start to 2022 World Cup qualification began on Wednesday with a 2-0 victory over Lithuania, and Bonucci tested positive a day later.
He had played the previous two games for his country, both 2-0 victories over Northern Ireland and Bulgaria.
He has started all but six of Juve’s league games this season, captaining the team before Giorgio Chiellini’s return from a long-term injury, but he is now expected to miss this weekend’s Derby Della Mole against Torino.
Juve’s next three games are against Napoli, Genoa, and Atalanta, and Bonucci could make his comeback in the last of those.
With 11 games remaining, Juventus is 10 points from the summit of Serie A.
Merih Demiral had previously returned to Turin after the international break after checking positive for Covid-19, according to Juventus.
With Bonucci and Demiral out, Chiellini and Matthijs de Ligt could get the start against Torino on Saturday.
Gianluigi Buffon is out due to a one-match ban for blasphemy, but Wojciech Szczesny has been preferred as the league’s No. 1 so far this season.
Paulo Dybala hasn’t played in the league since January, and Aaron Ramsey was sidelined with a thigh injury before the international break, but Alex Sandro could return.